Primary (spindle cell) Rhabdomyosarcoma of Submandibular Salivary Gland


Authors: Z. Kinkor 1;  M. Kracík 2;  A. Skálová 1
Authors‘ workplace: Bioptická laboratoř, s. r. o., Plzeň ;  vedoucí prof. MUDr. A. Skálová, CSc. Oddělení otorinolaryngologie, Oblastní nemocnice Jičín 1;  vedoucí prim. MUDr. M. Kracík 2
Published in: Otorinolaryngol Foniatr, 58, 2009, No. 2, pp. 106-109.
Category: Case History

Overview

Presented is an extremely rare case of the primary spindle cell rhabdomyosarcoma of submandibular gland in 55-year-old man. The multilobular tumorous mass measured up to 45 mm in maximum diameter, completely obliterated submandibular gland and extended into surrounding soft tissues. There was massive metastatic disease in the regional cervical lymph nodes at the time of diagnosis; the patient developed systemic dissemination in the lung, mediastinal lymph nodes and vertebral column three months after operation. Radiological, macroscopic and histological findings are broadly documented. Microscopy consisted of monotonous, fascicular spindle cell pattern lacking any organoid structures or epithelial formations. Furthermore, there was no clear-cut evidence of histogenetic orientation of the lesion by conventional hematoxylin-eosin stain. Immunohistochemistry confirmed diagnosis of rhabdomyosarcoma by expression of desmin and MyoD1. Discussed are both current rhabdomyosarcoma classification and its differential diagnosis in the background of spindle cell proliferations of salivary glands.

Key words:
submandibular salivary gland, sarcoma, primary spindle cell rhabdomyosarcoma.


Sources

1. Barnes, L., Reichart, P., Sidransky, D.: WHO classification of the tumors. Pathology and genetics. Head and neck tumors. IARC Press, Lyon, France, 2005, s. 275-276.

2. Benjelloun, H., Jouhadi, H., Maazouzi, A. et al.: Rhabdomyosarcoma of salivary glands. Report of 3 cases. Cancer Radiother., roč. 9, 2005, 5, s. 316-321.

3. Daou, R. A., Schloss, D.: Childhood rhabdomyosarcomas of the head and neck. 2 case reports on salivary glandular and paraglandular involvement. J. Otolaryngol, roč. 11, 1982, 1, s. 52-56.

4. Elboukhari, A., Errami, N., Hemmaoui, B.: Alveolar rhabdomyosarcoma of the parotid gland. Rev. Stomato. Chir. Maxillofac., roč. 108, 2007, 6, s. 536-538.

5. Ellis, G .L., Auclair, P. L.: Atlas of tumor pathology. Tumors of salivary glands. AFIP, Washington D.C., USA, 1996, s. 379-382.

6. Gogas, J., Markopoulos, C., Karydakis, V. et al.: Carcinosarcoma of submandibular salivary gland. Eur J. Surg. Oncol., roč. 25, 1999, 3, s. 333-335.

7. Kuhnen, C., Berger, P., Leuschner, I. et al.: Sclerosing pseudovascular rhabdomyosarcoma – immunohistohemical, ultrastructural and genetic findings indicating a distinct subtype of rhabdomyosarcoma. Virchows Arch., roč. 449, 2006, s. 572-578.

8. Kwon, M. Y., Gu, M.: True malignant mixed tumor (carcinosarcoma) of parotid gland with unusual mesenchymal component: A case report and review of the literature. Arch. Pathol. Lab. Med., roč. 125, 2001, 6, s. 812-815.

9. Lin, J., Yip, K. M., Chow, L.  T.: Pleomorphic rhabdomyosarcoma of the submandibular salivary gland. Otolaryngol Head Neck Surg., roč. 116, 1997, 4, s. 545-547.

10. Luna, M. A., Tortoledo, M. E., Ordonez, N. G. et al.: Primary sarcomas of salivary glands. Arch. Otolaryngol Head Neck Surg., roč. 117, 1991, 3, s. 302-326.

11. Mentzel, T., Kuhnen, C.: Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch., roč. 449, 2006, s. 554-560.

12. Parham, D. M., Ellison, D. A.: Rhabdomyosarcoma in adults and children. An update. Arch. Pathol. Lab. Med., roč. 130, 2006, s. 1454-1465.

13. Takama, A. Jr., Leon, J. E., de Alemeida, O. P. et al.: Nonlymphoid mesenchymal tumor sof the parotid gland. Oral Oncol., roč. 44, 2008, 10, s. 970-974.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)
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