Cetuximab in the Salvage Protocol for Local-Regional Advanced Carcinomas of Head and Neck: First Clinical Experience and Possibilities of Research in Predicting Efficiency of this Treatment

Authors: J. Neuwirthová;  R. Kostřica;  Z. Mechl;  P. Smilek
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku LF MU a FN, Brno přednosta prof. MUDr. R. Kostřica, CSc.
Published in: Otorinolaryngol Foniatr, 57, 2008, No. 4, pp. 226-229.
Category: Comprehensive Reports


The integration of EGFR inhibitors to the treatment of head and neck cancers means considerable advancement in oncology. Extracellular inhibitors show the effectiveness in the treatment of head and neck cancers. But only cetuximab in a combination with high dose radiation therapy is registered in the Czech Republic for locoregionally advanced diseases. The research of predictive markers is being carried out all over the world together with the EGFR inhibitors treatment.

Key words:
head and neck cancer, targeted therapy, EGFR inhibitor, cetuximab, EGFR, mutation, predictive marker.


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